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Breast Cancer 16, 180187
This creates a fundamentally different situation than traditional drug use
No serious adverse reactions were reported
Interestingly, several fragment hits originating from our second XChem screen possess alternative groups to the sulfonic acid that interact with R131 and R102, which opens up opportunities to link and merge hit matter found across the TIN2 leucine and phenylalanine binding pockets
Varadi et al., 2021), interactomes (Alanis-Lobato et al., 2016), regulatory networks (Ben Guebila et al., 2021), metabolic pathways (Kanehisa et al., 2019), cancer drivers (Martinez-Jimenez et al., 2020), disease-related genes (Arpi and Simpson, 2022), and more, for sample-derived knowledge