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3 Johns Hopkins Drug Discovery, Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA Correspondence: Soo Kyung Bae, College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon, 14662, Republic of Korea, Email [email protected] Abstract: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are peptide-derived analogs that were initially investigated to treat type 2 diabetes

Because baseline stabilization must be taken consistently and long term, tolerability is critical

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3 The angel face of branched-chain amino acids: beneficial effects 3.1 Muscle protection and anabolic support 3.1.1 Promotion of muscle protein synthesis Leucine-mediated activation of the mTORC1 pathway: BCAAs, particularly leucine, are key regulators of muscle protein synthesis