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According to IQVIA, this creates an unusually short branded exclusivity window: generic manufacturers are positioned to flood the market with lower-cost alternatives, potentially extending GLP-1 treatment to a far broader patient population

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The question of whether a very low-dose COC used continuously or progestin monotherapy is better may be of little relevance, and it is plausible that ensuring amenorrhoea is more important than the modality chosen to achieve these goals [65]

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The liver is always interacting with the gut-derived bacteria and microbial products, in a distinctive local immune environment, often hesitating in tolerance, since an intact intestinal epithelial barrier can protect the liver from an excess of gut bacteria and their metabolites [44]

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