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If the proposed mechanism (gradual synaptic plasticity effects) is right, daily dosing might be needed for sustained effect

PubMed Central, Shahid, Saleem Ullah, et al

Initially developed for type 2 diabetes, GLP-1RAs have demonstrated robust weight loss in randomized controlled trials and real-world settings, leading to their repositioning as cornerstone obesity treatments ( Human metabolic studies consistently show that reductions in energy intake account for most of the weight loss observed during GLP-1RA therapy, whereas increases in resting energy expenditure are modest or absent ( Beyond total weight loss, the quality of weight loss has become an increasingly important clinical concern

IPPC Climate Change 2022:Mitigation of Climate Change (eds Shukla, P

Most traditional metabolism supplements rely on caffeine, green tea extract, or capsaicin, which provide short-term thermogenic effects rather than sustained appetite regulation

Ideally, the chosen initial intervention for weight loss would also be effective for weight loss maintenance