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Jan 7, 2023, The New York Times

Consistent with this interpretation, a recent study concluded that OCT1 variants with loss of function do not alter metformin concentrations in healthy volunteers titrated to 1 g/day of metformin [27]

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Strategies for managing this period include maintaining close communication with your healthcare provider about side effects, using all available anti-nausea strategies proactively rather than reactively, accepting that some temporary discomfort accompanies effective treatment, focusing on the progress already made rather than the challenges remaining, and remembering that 85% of patients report minimal side effects by month four

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