Taurine levels in the cultured hepatocytes isolated from Cdo1 / mice ranged from 4.6 to 6.2 % of the corresponding wild-type levels (this study), whereas taurine levels in the liver of Cdo1 / mice fed on taurine-free diets were found to be consistently less than 5 % of the wild-type levels (previously published study)
No validated human pharmacokinetics A human half-life, bioavailability, tissue distribution, metabolic pathway and exposure-response relationship have not been established through a published clinical programme
G., Thorning, D
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