Both semaglutide and tirzepatide can contribute to GLP-1 related hair loss , primarily through the mechanism of rapid weight loss causing telogen effluvium, a temporary hair shedding condition
That is the mildest rating in the table
Lawsuits describe individuals hospitalized months, placed on permanent feeding tubes, or requiring gastric bypass surgery despite cessation
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Thyroid cancer The prescribing information for GLP-1RA lists MTC as a contraindication, based on a preclinical rodent study demonstrating that GLP-1R activation elevates cAMP levels in rodent thyroid C-cells, stimulates calcitonin release, and promotes C-cell hyperplasia and MTC development (200)
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