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Retatrutide, a GIP, GLP-1, and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial

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While both Retatrutide and tirzepatide (known commercially as Zepbound) are Eli Lilly products targeting GLP-1 receptors, Retatrutide's additional action on GCG might promote greater appetite reduction and weight loss

Without sufficient protein intake and the right exercise or muscle-stimulating protocols, up to 40% of weight lost on GLP-1 drugs like Ozempic and Wegovy can come from lean muscle mass, impacting strength and metabolism

Dulaglutide 0.75 mg (n = 251) resulted in a mean increase in 24-h HR of 1.3 bpm, whereas a 3.5-bpm increase in HR was observed at the end of the study for the 1.5-mg dose (n = 254)

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