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If you receive a product and check its pH and it is below 4.5, the copper peptide is likely partially degraded or destabilized

Each injection should be reported separately

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If you suspect you have experienced a side effect from any medicine or unlicensed substance, you can report it via the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk

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In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 100%, or higher than 100%, compared to an otic formulation that is not a controlled-release otic formulation