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A reader skeptical of the inferential leap from the broader microneedling and delivery-enhancement literature to the specific at-home microinfusion protocol has a defensible position

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In the context of hepatic ischemia-reperfusion injury associated with liver surgery, SS-31 can inhibit M1 polarization of macrophages, reduce pro-inflammatory cytokines, and thereby alleviate liver injury by scavenging ROS and regulating STAT1/STAT3 signaling (108)

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