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This uncoupling is clinically relevant because it suggests the bone density changes seen in the Hansen trial are not simply a transient effect of weight loss but may reflect a direct or indirect metabolic effect of GLP-1 receptor activation on bone turnover
They act as antioxidants, support gut bacteria, and some studies suggest they may enhance GLP-1 production and inhibit DPP-4 (an enzyme which breaks down GLP-1) [6]
GLP-1RAs lower plasma lipid levels and lower blood pressure, both of which contribute to a reduction of atherosclerosis and cardiovascular disease (31)
This combines probiotics (the beneficial bacteria) with prebiotics (their favourite food), creating an environment where GLP-1-supporting microbes can truly flourish
Fortunately, GLP-1RAs seem to have the potential to become a multi-target medicine
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