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Besides, energy dissociation component analysis revealed the contribution of G Bind Coulomb (Coulomb energy) and G Bind vdW (Van der Waals interaction energy) to the stability of the complex while G Bind Covalent (Covalent energy) and G Bind Solv GB (Generalized Born electrostatic solvation energy) tends to separate the interacting receptor and ligand in both the docked complexes and during MD simulation (Table S3, Fig

This results in substantially higher free peptide bioavailability at the muscle IGF-1R compared to equimolar native IGF-1 in serum-containing research systems an important consideration for in vitro experimental design where IGFBP concentrations vary by medium formulation and serum lot

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Lyophilized (unreconstituted): Store at 20 C (4 F) or below in dry, dark conditions