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3.1.1 Impact of ROS on cellular function and atherosclerosis Elevated ROS can induce endothelial cell dysfunction or death, disrupting the vascular barrier and leading to vasoconstrictive and vasodilatory dysfunction, vascular smooth muscle cell proliferation and migration, inflammatory responses, and thrombosisprocesses intimately associated with various cardiovascular disorders, including atherosclerosis, hypertension, and CHD (31)

Adjust nutrition or training load

For a drug class whose benefits blood sugar control, weight reduction, cardiovascular protection are long-term and cumulative, discontinuation means losing those benefits

For Tennessee patients, understanding how its cost compares with injectable alternatives can inform treatment decisions