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Interestingly, IDO1 is closely associated with chronic inflammatory responses [61, 62] and increased IDO1 activity through upregulation, then alters the ratio between kynurenine and tryptophan [63]

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It is paramount that these probiotics efficacy, especially in reducing uremic toxins by modulating the gut microbiota, be further investigated in CKD patients

In addition to the analyses on the relative abundance data mentioned above, taxa were summarized using the Python script labeled QIIME Scripts compilation in the Supplementary Materials Scripts .zip file