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Its role is context-dependent, functioning as either a pro-survival mechanism that confers resistance or a process that can be co-opted to enhance drug sensitivity

Effect of various PDE inhibitors on smooth muscle tone and cyclic nucleotide levels in vitro

These are typically intramuscular injections starting with high doses weekly, then switching to monthly 1,000 mcg doses for the rest of a patients life (No Stomach for Cancer, 2023)