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Health Canadas hydroxyzine safety review notes that the elimination half-life can extend to 29.3 hours in the elderly , which raises the risk of prolonged sedation and supports cautious dosing in that group

Further research with large-scale sample sizes, varying designs and doses, over a longer duration, and with diverse participant groups are needed to substantiate current findings

Injection site reactions were most common with the loading (initial) dose

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Use In Pediatrics Contraindicated RYBELSUS 7MG TABLET is not recommended for children and adolescents below 18 years of age as safety and efficacy are not established