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In three nested casecontrol studies from England and Wales, involving 440,089 patients with T2DM and without ASCVD treated with non-insulin glucose-lowering medication, combined SGLT2i and GLP-1RA therapy used for primary prevention was associated with 30% lower odds of MACE (defined as myocardial infarction/acute coronary syndrome, stroke/transient ischemic attack, and/or cardiovascular death) compared with other combination regimens (OR, 0.70

Bhm M, Wolff I, Scholzen TE, Robinson SJ, Healy E, Luger TA, et al

Mari, M., Morales, A., Colell, A., Garcia-Ruiz, C

Variations in the GLP1R gene, GIPR gene, and serotonin-pathway genes influence both therapeutic response and the likelihood of experiencing anxiety during treatment

The most frequent associated risk factor was blood transfusion (72.5%)

Although he adhered to the dietary protocols, his food intake was adjusted according to his satiety levels