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Although GRK3 appears to mediate acute fentanyl-induced antinociceptive responses in the hotplate and tail-flick assays, the GRK2 isoform may be involved in MOR regulation in other neural circuits (Gabra et al., 2008

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Briefly, 2 10 5 human NK cells and 2 10 5 cells of the erythroleukemia cell line K562 (American Type Culture Collection) were mixed by gentle pipetting, spun down for 1 min at 1000, r.p.m

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