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Notably, there is evidence that the pro-inflammatory cytokine IL-1 plays a role in exacerbating tau pathology by accelerating tau phosphorylation (38)

They are widely distributed throughout the body, including significant expression in the brain, particularly in regions involved in cognition, memory, and neuroprotection

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Propensity score matching (1:1) was used to balance baseline demographics, comorbidities, and laboratory parameters