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If you notice stool colour changes whilst taking GLP-1 medication, consider recent dietary intake and any new medications or supplements before attributing the change to your GLP-1 therapy
GLP-1 medications like semaglutide and tirzepatide have become widely used among women for weight loss, but the conversation around how they interact with estrogen, insulin, the menstrual cycle, thyroid function, and fertility is still catching up to the pace of prescribing
You start at the lowest dose (.25mg), you lose 6 pounds and then you plateau, then you go to .5mg, lose some more, then 1mg, then 1.5, and on up to 2mg
The first readout, TRIUMPH-1 (obesity), was reported on 21 May 2026, with 28.3% mean weight loss at 80 weeks in the 12mg cohort (Pharmaceutical Journal)
They are uncomfortable but not dangerous
Users wearing continuous glucose monitors report pasta peaks about ten to twenty points lower after a week
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