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Constitutive overexpression of the proto-oncogenes c-myb in Balb/c-3T3 cells increases expression of both IGF-1 and IGF-1R, at least partly through an increased transcriptional activity and in this way abrogates the requirement for IGF-1 in the growing media (Kim et al, 1996)

For overdoses discovered beyond the first hour, medical care focuses on managing symptoms and monitoring for complications

FS-344 is preferred for injection because it is more stable as a recombinant protein and converts to FS-315 systemically

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