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Specifically, when schisandrin IV is co-administered with ginsenoside Rg1, Rb1, or notoginsenoside R1, it exhibits significant activation of the Nrf2/HO-1 signaling pathway after cerebral I/R, which is not observed with its individual application

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For others with adequate baseline levels, monitoring at 3 and 6 months guides later supplementation decisions, avoiding unnecessary pills while protecting those truly at risk

doi: 10.1016/j.it.2018.04.002 5 Allam-NdoulB.Pulido-MateosE