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When glutathione-dependent antioxidant systems are deactivated, harmful lipid reactive oxygen species (L-ROS) build up and cause ferroptosis [47, 74]

This scan is 3D

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The receptor exists in two splice variants: the active GHS-R1a, which binds acylated ghrelin, and the truncated GHS-R1b, which is pharmacologically inactive but can modulate the activity of 1a through heterodimerisation