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This damage might not even be visible, but it can destroy the vial's sterility

Temperature Fluctuations: Leaving the vial out for extended periods or storing it in a fridge with poor temperature control can weaken the preservative's efficacy

Sterile technique fundamentals Every interaction with the vial is a potential contamination event

Additionally, if they have parts of the inflamed terminal ileum removed, the risk for malabsorption is increased

10.1016/j.ijbiomac.2019.05.188 113 SunC.ZhengW.WangL.DuQ

Like much of the NICE guidance, it is not necessarily designed with GPs in mind, but I often find it useful if I need more detail