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Furthermore, previous studies linked mechanical injury to the inhibition of Nrf2/antioxidant response element (ARE) signalling, which mediates transforming growth factor (TGF)-1/Smad3 signalling

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Future studies should explore whether perioperative hydration protocols, electrolyte monitoring, or cardiovascular screening could help mitigate these risks while maximizing the benefits of GLP-1 agonists in orthopedic surgical populations

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