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It is caused by the accumulation of misfolded or unfolded proteins in the ER lumen, resulting in overexpression of ER stress markers such as growth arrest and DNA damage-inducible protein 153 (CCAAT/enhancer binding protein homologous protein), glucose-regulated protein 78 (GRP78), and C/-EBP homologous protein (CHOP)
Mild possible effects: injection site irritation, headache, fatigue
Because they contain growth factors that help support tissue repair and cellular activity
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Symptoms might include itching, rash, or hives
Int J Exp Pathol (1998) 79(6):34757
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