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Moreover, TMAO activated the farnesoid X receptor (FXR) and small heterodimer partner (SHP), downregulating the expression of hepatic BA synthase cytochrome P450 family 7 subfamily A member 1 (CYP7A1), cytochrome P450 family 27 subfamily A member 1 (CYP27A1), and BA transporter organic anion-transporting polypeptide (OATP) in ApoE -/- mice (70)

A close relationship between hearing loss and cognitive disorders has been identified

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As liver iron overload is a hallmark of ALD, it would be interesting to investigate whether some iron homeostasis-related molecules could serve as biomarkers predicting ALD risks in alcoholics