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Genetic variants in pain-processing pathways, serotonin metabolism, and appetite regulationsuch as those in the GLP1R and GIPR genesmay contribute to baseline migraine predisposition and influence how your body responds to peptide-based medications

Healthcare providers may avoid prescribing Saxenda for people with: A history of pancreatitis Gallbladder problems Heart problems Kidney or liver disease Thyroid disorders (like medullary thyroid carcinomaor MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Diabetic ketoacidosis Digestion problems High cholesterol or triglyceride levels Saxenda may not be prescribed to pregnant women, women who are trying to conceive, or women who are breastfeeding

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