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Preclinical Studies in Ototoxicity Models A study carried out both in cultured cells and in an animal model (male and female mice) demonstrated the strong beneficial potential of ALA in rescuing ototoxic hearing loss caused by cisplatin

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[(accessed on 31 October 2023)]

To study these enzymatic processes with oxidation- reduction rotations, especially the mechanism of the methylcobalamin cofactor in biochemical processes dependent on it, the electrochemical method of cyclic voltammetry was used [5,6,7,8]

APAP can be synthesized in the body through O-dealkylation of the prodrug phenacetin, a pain-killer that was withdrawn from the market due to nephrotoxicity and carcinogenesis [3]