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These compounds influence critical inflammatory pathways, such as mitogen-activated protein kinases and NF-B signaling pathways, and promote the production of anti-inflammatory cytokines IL-1ra (You et al., 2020)

For comparison, in the table below, we also show those GLP-1 agonists with active ingredients only approved for treatment of diabetes that have less potential for off-label weight loss use (Bydureon BCise, Trulicity)

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Int J Sports Med 1994;15(4):181-185

Carcinogenesis 36(Suppl 1):S128S159

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