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Dose-response analysis revealed a similar IC 50 value (the drug concentration that inhibited 50% cell viability) in both melanocytic cell lines (A375 = 8.4M 0.2 M and SK-MEL-28 = 8.7M 0.15 M) (Figure 1)

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PUFA-CoAs are subsequently used for the synthesis of phospholipids, including phosphatidylethanolamine, and loss of ACSL4 results in significant resistance to ferroptosis induced by GPX4 deficiency [41]