BDNF heterozygous mice demonstrate age-related changes in striatal and nigral gene expression
Postmortem analysis has revealed that insulin resistance (IR) also occur in AD patients brain with significantly decreased expression of the insulin receptor, concomitant with the disease progression (66, 67) and indicated that the defects in insulin signaling are associated with AD pathogenesis (68)
But for millions of people already weighing whether to start a GLP-1 drug for diabetes, obesity or another approved indication, it is one more factor worth considering
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Frank AR, Li V, Shelton SD, et al
i.c.v., intracerebroventricular