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Overrepresentation of pathways related to blood coagulation, folate metabolism, and IL-17 was observed in gallstone bile

Importantly, functional analysis showed the transcriptome included nearly all enzymes for key metabolic pathways, specifically 21 of 22 enzymes involved in aromatic amino acid synthesis and all eight enzymes required for branched-chain amino acid (Clouse et al., 2016)

Severe infections remain a concern as many of these patients are already receiving other immunosuppressive medications

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The timing of HRT initiation matters (earlier is generally better, ideally within 10 years of menopause onset) [9]

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