Quick Answer: Most patients require long-term GLP-1 therapy because stopping these medications typically results in weight regain and worsening blood sugar control, as they treat chronic conditions like type 2 diabetes and obesity
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Mulla Y, Markey KA, Woolley RL, Patel S, Mollan SP, Sinclair AJ
Akkermansia populations may increase
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Within the hypothalamus, GLP-1 interacts with pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (it seems to have limited direct access here), a classic site involved in appetite regulation and energy expenditure