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Plasma membrane-tethered G proteins have been shown to be basally preassembled with GPCRs in some cases [50, 51], in contrast to cytoplasmic GRK2 or -arrestins, that need to be recruited to the plasma membrane upon GPCR stimulation

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The discontinued NCT02472717 trial investigating liraglutide in PsA further illustrates both the pioneering nature and the challenges inherent in this research field (82)