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10.1123/ijsnem.2021-0090 [DOI] [PubMed] [Google Scholar] Mitchell ES, Slettenaar M, vd Meer N, Transler C, Jans L, Quadt F, Berry M (2011) Differential contributions of theobromine and caffeine on mood, psychomotor performance and blood pressure

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Many treatments approved for T2DM treatment such as sulphonylureas and thiazolidinediones (TZDs) improve glucose metabolism but have the unwanted side effect of causing weight gain (Thule and Umpierrez, 2014) and (Kahn et al., 2006

[DOI] [PMC free article] [PubMed] [Google Scholar] Micha R, Wallace SK, Mozaffarian D

This is where the concept of bioavailability becomes the most important part of the conversation

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