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The new concept implicates reduced ceruloplasmin ferroxidase activity, which is typically low in Wilson disease, resulting in decreased circulating iron and increased hepatic iron storage [132]

Nature 618 , 144150 (2023)

Instead, it supports melanin balance from the inside by shifting melanin production pathways under certain conditions, while also calming oxidative stress that triggers pigmentation

13-1-15859-5-1328 : 40 (20 ) / 1 (2,000 .)

and the FI group up-regulated 28 differential metabolites and down-regulated 32 differential metabolites relative to the GSH group

Other inhibitors Paricalcitol restores GPX4 expression by activating VDR, improves renal function, reduces mitochondrial damage, and alleviates cisplatin-induced AKI [163, 171, 179]