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Which approach is better depends entirely on your situation, goals, and what you plan to do after the medication stops

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A dual agonist activates two incretin receptors (tirzepatide: GIP + GLP-1)

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Selective reversible inhibition of liver carnitine palmitoyl-transferase 1 by teglicar reduces gluconeogenesis and improves glucose homeostasis

There is some evidence suggesting that weight cycling has no effect on the risk of type 2 diabetes [49], and there is no conclusive evidence that previous weight cycling affects body composition or predisposition to obesity