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Chiang JL, Shukla P, Pagidas K, Ahmed NS, Karri S, Gunn DD, et al
No.: HY-138153CAS No.: 2421119-60-8Purity: 99.97%JKE-1674 is an orally active glutathione peroxidase 4 ( GPX4 ) inhibitor and an active metabolite of GPX4 inhibitor ML-210
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This indicates that survival is critically dependent upon GSH, and therefore is not being sustained by an alternative Trx-disulfide reductase, such as by repurposing of either the mitochondrial TrxR2 or the testis-specific Tgr (TrxR3) [48, 109]
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