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The confirmed harms were a small increase in liver enzymes, a roughly 1% incidence of muscle symptoms, and a modest rise in blood sugar in patients already near the diabetes threshold

The researchers also found no association between higher IGF-1 and cancers like lung, kidney, or bladder cancer

Many nutrients have their action INSIDE the cell, which means that testing serum and blood levels just give us an indication of what may be available but that is assuming everything else is working properly: cellular activity, enzyme activity, receptor activity, etc

10.1038/nm1075 7 ChangC

Seek immediate medical attention if severe symptoms occur