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In a larger clinical study involving 479 patients with chronic primary glomerulonephritis, the combination of AC, isolated from Rehmannia glutinosa , and irbesartan led to a 36.42% reduction in proteinuria significantly greater than the 27.97% reduction observed in the control group receiving irbesartan alone (Qiu et al

In accordance with this hypothesis, breakthrough, relapse and ultimate nonresponse were predicted for TMA-positive but PCR-negative patients