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Conclusion: Recognizing and Addressing Low Brain Folate in Autism and Neurological Disorders Low brain folate due to folate receptor autoantibodies (FRA) is a frequent but often overlooked condition, especially in autism, seizures, and other neurological disorders

Because robust human safety data are limited, it is difficult to give a definitive side-effect profile with meaningful incidence rates

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10.1126/science.aaf5171 178 MayersJ

In DR, for example, hyperglycemia-induced vascular damage is accompanied by neuroinflammation and oxidative stress