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It can then cause dysfunction of these brain cells, including increasing microvascular endothelial cells permeability, leucocyte adhesion, procoagulant activity, and reducing the availability of nitric oxide through various biochemical pathways initiated by mitochondrial overproduction of reactive oxygen species (124)

Feyz Med Sci J

Epidemiology of peripheral neuropathy and lower extremity disease in diabetes

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Folic acid therapy also resulted in higher pregnancy and live birth rates in men with the MTHFR 677 TT genotype, but this effect did not reach statistical significance

9ad), but none of these isoforms displayed a dependency in cancer cell line genetic screens (Extended Data Fig