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In theory, direct PKA-driven activation of uncoupling proteins may accelerate mitochondrial fat oxidation

Survodutide, while showing lower weight loss (18.7% in Phase 2), has demonstrated particular promise for MASH treatment with Breakthrough Therapy Designation and dedicated Phase 3 MASH trials

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Unlike naturally occurring GLP-1R agonists, exendin-P5 contains a unique N-terminal sequence (Figure 1A)

Tirzepatide activates the following gut hormone receptors: GLP-1 (glucagon-like peptide-1) GIP (glucose-dependent insulinotropic polypeptide) This process reduces hunger while delaying food from getting to the small intestine

Comp Immunol Microbiol Infect Dis 4:175