doi: 10.1016/j.ceca.2012.03.003
The FDA-approved schedule from the prescribing information is [1]: | Week | Dose | Purpose | |------|------|---------| | 1 to 4 | 0.25 mg | Initiation (not a therapeutic dose) | | 5 to 8 | 0.5 mg | First therapeutic dose | | 9+ | 1.0 mg | Standard maintenance if additional glycemic control needed | | 9+ | 2.0 mg | Maximum dose for patients not reaching HbA1c target on 1.0 mg | The 0.25 mg dose is strictly for GI acclimation
Symptoms can range from abdominal pain and cramping to fever, nausea, and changes in bowel habits
Thus, micronutrient supplementation, especially in individuals with overt or marginal deficiencies, could possibly improve overall mood state and psychological well-being
Risks in children and pregnancy Children and pregnant people Berberine also has links to bilirubin buildup in infants
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