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Concurrently, vitamin B12 deficiency was identified as a significant public health concern, particularly among vulnerable populations such as the elderly and developing embryos, where insufficient B12 levels have been associated with an increased risk of neural tube defects

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Second, the inability to quantify central nervous system (CNS) GSH concentrations in vivo has substantially hindered therapeutic trials targeting CNS augmentation

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Manov I, Hirsh M, Iancu TC (2004) N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis