In 2017, a small single-center randomized trial of 62 participants, but with longer follow-up, found benefit with exenatide given once weekly (see graph below)
Unit marks are also expressed in mLs and can be interchangeably referenced
Digital weight loss company Noom has entered the evolving GLP-1 medication landscape with the launch of its Noom Microdose GLP-1Rx Program, offering members personalized microdoses of GLP-1 medications combined with behavioral coaching and clinical support
Medication Mechanism of Action Average Weight Loss Retatrutide Triple agonist (GLP-1, GIP, Glucagon) Up to 24% average weight loss over 48 weeks Semaglutide GLP-1 receptor agonist Up to 17% over 68 weeks Tirzepatide Dual agonist (GLP-1, GIP) Up to 25% over 52 weeks Retatrutide is used to help with weight loss
Still, with the recent introduction of oral semaglutide (Rybelsus), accessibility has improved
Novo Nordisk Inc