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Conversely, the chronic exposure to the GLP-1RA Exendin-4 (Ex4) reduced the hypothalamic expression of the kisspetptin-1 (Kiss-1) receptors, with a marked reduction of the preovulatory LH peak and a delayed puberty onset [35]

doi: 10.1056/NEJMoa2306185 47 Elafibranor long-term efficacy and safety and impact on fatigue in primary biliary cholangitis: interim results from the open-label extension of the ELATIVE trial up to 3 years

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NADPH = reduced nicotinamide adenine dinucleotide phosphate

Review article: drugs interfering with visceral sensitivity for the treatment of functional gastrointestinal disorders--the clinical evidence