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One study revealed that mice with system Xc knockdown showed rapidly advancing retinal aging, increased retinal strain, elevated ROS levels, and compromised mitochondrial activity, providing a beneficial framework for investigating retinal aging and AMD (224)

The study showed a biomarker effect

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2Perform hand hygiene and don appropriate PPE (gloves, gown, mask) in accordance with institutional SOP

This limits macrophage polarization toward the M1 pro-inflammatory phenotype

The surface was washed between samples with 25 mM NaOH for 4 s followed by equilibration with running buffer