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INTRODUCTION The glucagon-like peptide-1 receptor (GLP-1R) is widely expressed in many tissues and mediates the action of the gastrointestinal peptide hormone, glucagon-like peptide-1 (GLP-1) 1

Darkening of Skin and Gums: A peculiar side effect seen in about 1% of female trial participants was hyperpigmentation darkening of the gums or skin (particularly on the face and breasts)

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Dapagliflozin is a weak substrate of the P-glycoprotein (P-gp) active transporter, and dapagliflozin 3-O-glucuronide is a substrate for the OAT3 active transporter